*To search the groups of press , associations, businessmen, sponsor for site News-art-culture.com*.The importance of vaccines. Why we need to be vaccinated? The characteristics, collaterals effects. Which are the mandatory vaccines? There are the questions at which we are interest to answer. Principally we are in grade of know the pathogens agents and our immunity where enter in major part the interest for survive searching the prophylaxis, methods of fighting and health.  The vaccination or prophylaxis vaccine active the metabolism for produce the antibodies which the scope of development a system of defense against a bacteria, virus or others microorganisms. A times which the vaccines is fundamental for the health to reduce the incidence of diffusion from grave and lethal diseases. The vaccine is discovery in 1796 year by the English  doctor Edward Jenner with  the significant ” vacca” from the diseases named bovine variola  appears from milking women at which comes inoculated a serum takes from pustule of bovine variola blocking the development from infection versus a pathogen agent, afterward the doctor researcher Luis Pasteur discover a prepared ” vaccine” by altered microbes  for creating the immunity against a pathogen agent. Into the vaccination history  The Organization Mondial of Health with the 1980 year has eradicate the variola. The vaccines become the mandatory for law or recommended following a vaccinal calendar. In travels , in the states or zones with high risk of  endemic where are evidenced the infective pathology  there are conciliate vaccines for impeding the diffusion of pathologic infections.  The Organization Mondial of Health propose  the 6th vaccines in program of vaccinations( for diphtheria, tetanus, pertussis, polio, measles and tuberculosis). The  principal characteristic of the vaccines is to produce the immunity of masse ( immunising the major part of people for having a minor probability to enter in contact with the pathogen , blocking the diffusion of infection’s catena. The vaccines can have the collaterals effects , complications , risk of lethal incidence , but all depend of metabolism and the individual immunity , them efficacy is the security, control, to produce the antibody for activating the immunity system.